Last offers update: February 26
Weight loss injections work by mimicking hormones that naturally regulate appetite and digestion in your body. These medications reduce hunger, increase feelings of fullness, slow down digestion, and decrease cravings for high-calorie foods. Most patients notice reduced appetite within the first few weeks of starting treatment.
Clinical studies show impressive results: patients lose an average of 10-20% of their body weight over 6-12 months when combining injections with healthy lifestyle changes. These outcomes significantly outperform traditional diet and exercise approaches alone, making weight loss injections one of the most effective medical treatments available for obesity.
The FDA has approved several weight loss injection medications for adults with obesity or those who are overweight with related health conditions like high blood pressure, diabetes, or high cholesterol. When used as prescribed and combined with a reduced-calorie diet and increased physical activity, these injections help patients achieve meaningful and sustainable weight loss.
When choosing a weight loss injection service, you'll encounter two main types of medications: brand-name and compounded versions. Brand-name medications like Wegovy, Mounjaro, and Zepbound are FDA-approved formulations that have undergone extensive clinical testing. These medications follow strict manufacturing standards and provide consistent quality, but typically cost $1,000-$1,500+ per month without insurance coverage.
Compounded medications are custom-made by licensed specialty pharmacies using the same active ingredients as brand-name versions. They offer significant cost savings—often $199-$399 per month—making treatment accessible to patients who cannot afford brand-name options or whose insurance doesn't provide coverage. While compounded medications have slightly less regulatory oversight, they are produced by licensed pharmacies following established pharmacy compounding regulations.
Most telehealth weight loss services featured in our comparison offer compounded medications as their primary option, with brand-name alternatives available for patients who prefer FDA-approved formulations. Your healthcare provider can help you determine which option is best for your individual situation, budget, and health needs.
Weight loss with injections follows a gradual, progressive pattern. Most patients notice initial appetite reduction within 1-2 weeks of starting treatment. Measurable weight loss typically appears within 4-8 weeks, with significant results occurring over 3-6 months of consistent treatment combined with healthy lifestyle changes.
Treatment begins at a low starter dose that gradually increases over several months. This slow escalation helps minimize side effects and allows your body to adjust comfortably. Your healthcare provider will monitor your progress and adjust your dosage based on your individual response and tolerance.
Long-term commitment is key for sustained results. Research shows that patients who stop treatment often regain about two-thirds of lost weight within one year. This doesn't mean you must stay on medication forever, but it highlights the importance of developing sustainable healthy habits during treatment. Your provider will help you create a long-term weight management plan that works for your lifestyle.
Like all medications, weight loss injections can cause side effects, though most are mild and manageable. The most common side effects include nausea, vomiting, diarrhea, constipation, and abdominal discomfort. These symptoms typically occur when starting treatment or increasing doses, and usually decrease as your body adjusts to the medication.
You can manage side effects effectively by taking your medication with food, staying well-hydrated, eating smaller meals throughout the day, and avoiding fatty or spicy foods that may trigger nausea. Starting with the lowest dose and increasing gradually also helps your body adjust more comfortably. If side effects become severe or persistent, contact your healthcare provider—they can adjust your dose or provide additional strategies to help.
Most patients find that side effects are temporary and well worth the weight loss results they achieve. The services we've reviewed provide 24/7 support and regular check-ins with healthcare providers who can help you navigate any challenges during your treatment journey.
Selecting the best weight loss injection service depends on your personal priorities, budget, and health goals. Consider these important factors: total monthly cost including any membership or support fees, what services are included in the price, available medication options, how much provider access you'll have, whether they operate in your state, and any refund or guarantee policies.
If affordability is your main concern, Hims and MEDVi offer the lowest monthly costs starting at $199-$299. For comprehensive support beyond just medication, Fridays Health includes unlimited provider visits, coaching, dietitian support, mental health counseling, and fitness app access—all in one transparent monthly price. Mochi Health stands out by including registered dietitian consultations in all plans, a valuable feature most competitors charge extra for.
Women seeking specialized care should consider Hers, which focuses specifically on female health needs and offers flexible options between injectable and oral medications. If you want financial protection, MEDVi provides a money-back guarantee framework with locked-in refill prices. For those prioritizing a holistic approach, Remedy Meds combines medication with comprehensive lifestyle coaching and reports impressive success rates with 94.6% of members achieving meaningful weight loss.
The cost of weight loss injections varies significantly depending on whether you use insurance or pay out-of-pocket. Many insurance plans cover brand-name medications with prior authorization, though requirements differ—some require documentation of previous weight loss attempts or specific health conditions. Insurance typically doesn't cover compounded medications since they're not FDA-approved as complete formulations.
For patients paying out-of-pocket, compounded medications offer the most affordable option at $199-$399 per month compared to $1,000-$1,500+ for brand-name versions. Calculate your true monthly cost carefully: some services charge separate fees for medication, membership, lab work, and coaching, while others include everything in one flat price. Most services offer significant discounts—20-50% savings—for committing to 6-12 month plans, though this requires upfront payment.
When comparing costs, consider the total value you're receiving, not just the medication price. Services offering coaching, dietitian support, and mental health counseling may cost more initially but could improve your success and long-term results. Many of the telehealth services we've reviewed offer insurance coordination assistance to help you understand your coverage options and identify the most affordable path forward.
Weight loss injections work best when combined with healthy lifestyle changes. While the medication reduces your appetite and helps control cravings, you'll achieve the best results by eating a balanced, reduced-calorie diet and staying physically active. Focus on meals rich in protein, healthy fats, fruits, vegetables, and whole grains. Many successful patients aim for 1,200-1,500 calories daily, though your healthcare provider or dietitian will give you personalized recommendations.
Regular physical activity accelerates weight loss and improves your overall health. Start with achievable goals like 30 minutes of moderate exercise, 5 days per week, and gradually increase as your fitness improves. Mix cardiovascular activities like walking, cycling, or swimming with strength training to maximize fat loss while maintaining muscle mass. The medication makes exercise easier by reducing appetite-driven fatigue and boosting your energy levels.
When comparing costs, consider the total value you're receiving, not just the medication price. Services offering coaching, dietitian support, and mental health counseling may cost more initially but could improve your success and long-term results. Many of the telehealth services we've reviewed offer insurance coordination assistance to help you understand your coverage options and identify the most affordable path forward.
Don't overlook the psychological aspects of weight loss. Working with coaches, dietitians, and mental health professionals—services included in comprehensive programs like Fridays Health and Mochi Health—helps you address emotional eating, manage stress, and build sustainable habits that last beyond medication. Support groups and community connections provide accountability and motivation throughout your journey.
Weight loss injections aren't appropriate for everyone. You should not use these medications if you have a personal or family history of certain thyroid cancers, specific endocrine conditions, severe pancreatitis history, or certain psychiatric or gastrointestinal conditions. These medications are not recommended during pregnancy, while trying to conceive, or while breastfeeding.
Weight loss injections may reduce the effectiveness of birth control pills. If you use oral contraceptives, discuss alternative methods like condoms, IUDs, patches, or rings with your healthcare provider before starting treatment. Always inform your provider about all medications and supplements you take to avoid potential interactions.
Regular medical supervision is essential throughout your treatment. Your provider will monitor your progress, adjust your dosage as needed, and conduct necessary health screenings to ensure safe treatment. Only use licensed telehealth services and U.S. pharmacies—never purchase medications from unregulated sources or international pharmacies, as counterfeit products pose serious health risks.
This information is for educational purposes only and does not constitute medical advice. Weight loss injections are prescription medications that require evaluation and ongoing supervision by a licensed healthcare provider. Individual results vary based on many factors including genetics, metabolism, age, diet quality, exercise habits, and medication adherence.
Consult with a qualified healthcare professional to determine if weight loss injections are appropriate for your specific health situation and which service best meets your needs. All treatment decisions should be made in consultation with your healthcare provider who has reviewed your complete medical history and current health status.
Treatment effectiveness depends on combining medication with lifestyle modifications including a reduced-calorie diet and increased physical activity. Weight regain is common after stopping medication, which highlights the importance of developing sustainable healthy habits during treatment. The information presented here is based on clinical research and user experiences but does not guarantee specific outcomes for any individual.
Weight loss injections work by mimicking hormones that regulate appetite and digestion. They reduce hunger, increase feelings of fullness, slow digestion, and decrease cravings for high-calorie foods. Most patients notice reduced appetite within the first few weeks of treatment.
Most patients notice initial appetite reduction within 1-2 weeks. Measurable weight loss typically appears within 4-8 weeks of consistent treatment. Significant weight loss usually occurs over 3-6 months. Results vary based on medication type, dosage, diet, exercise, and individual metabolism.
Average weight loss ranges from 10-20% of body weight over 6-12 months. Some patients lose more, some less, depending on individual factors like metabolism, medication adherence, diet quality, and exercise consistency. Your healthcare provider can discuss realistic expectations for your specific situation.
Yes. Weight loss injections are most effective when combined with a healthy diet and regular physical activity. The medication makes healthy choices easier by reducing appetite and cravings, but lifestyle changes are essential for lasting results.
Weight regain is common after stopping treatment. On average, patients regain about two-thirds of lost weight within one year after discontinuing medication. This is why many providers recommend continued treatment or transitioning to sustained lifestyle changes to maintain results.
The most common side effects are nausea, vomiting, diarrhea, and abdominal discomfort. These often decrease over time as your body adjusts. Management strategies include taking medication with food, starting with lower doses, staying well-hydrated, eating smaller meals, and avoiding fatty or greasy foods.
Weight loss injections have been studied extensively and approved by the FDA for weight loss treatment. However, they're not appropriate for everyone. Medical evaluation is required to determine if injections are safe for your individual health situation. Always inform your provider about all health conditions and medications.
Yes, weight loss injections may reduce the effectiveness of oral contraceptive pills. If you use birth control pills, discuss alternative contraception methods (condoms, IUDs, implants, patches) with your healthcare provider.
Consider these factors: total monthly cost (including any membership fees), what services are included (coaching, dietitian support, mental health services), medication options available, provider access, state availability, and refund/guarantee policies. Compare long-term costs, not just first-month pricing.
Compounded injections are custom-made by specialty pharmacies and cost significantly less ($199-$399/month). Brand-name injections are FDA-approved, clinically tested, and cost more ($1,000-$1,500+/month). Both contain the same active ingredients. Your provider can recommend which is appropriate for you.
